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Natural Beauty


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D’DIFFERENCE is the science of skincare. Invented by an MD, developed by chemists in our own labs, and produced with cold-mixing technology, our active ingredients are 100-percent natural.

We use organic ingredients when possible, but we are not blindly devoted to them — what best creates healthy skin is maintaining the skin’s proper pH level. Our credo: minimum ingredients make for maximum impact.

D’DIFFERENCE is a natural version of products originally created for use by physicians to solve acute clinical problems. True to our medical roots, D’DIFFERENCE products are formulated through evidence-based results from extensive testing, yet our Nordic heritage means we embrace the natural, living as part of nature, never separate.

In this age of eco, it seems everyone with a kitchen is creating skincare products. But we take pride in the fact that ours are backed by science, meet ISO 9001 production standards, and leave the skin healthy both inside and out.


D’DIFFERENCE  products contain a great variety of active ingredients, each of them having its own unique and valuable features. 

HYDRESIA® emulsion* consists of natural oleosomes from safflower seeds, and its function is to retain the healthy level of moisture and nutrients in the skin. Safflower oleosomes act as natural water and nutrients’ reservoirs. When skin needs additional moisturizing or nutrition, oleosomes help to release them gradually, making the skin look youthful and bright during longer periods of time. 

Plant-Derived Stem Cells Extract is included in D’DIFFERENCE Cell Innovation products. It is a very efficient anti-ageing component stimulating collagen synthesis and the renewal of skin cells, it decreases the depth and length of wrinkles and also prevents the formation of new wrinkles. 

As we age, the production of collagen in our body slows down. Since the plant stem-cell component has the potency to promote collagen production and to activate cells, you can expect your skin to rejuvenate. 

Persian Silk Tree Extract*
For the first time in the cosmetics industry, an active ingredient is demonstrating a lifting action on sagging upper eyelids. It offers a gentle alternative to invasive surgery to lift the upper eyelid, reduce crow’s feet wrinkles, fade away dark circles and diminish puffiness.
*ECOCERT approved

Peptides, Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 are there to ”attack” the dark circles. These powerful peptides reinforce firmness and tone of the eye area. They also activate the elimination of blood originated pigments responsible for the colour in the dark circles and local inflammation.

Hyaluronic Acid* is found in every human body. It is the key component of the extracellular matrix which is the space filler of the supporting scaffold cells. It allows skin cells to retain moisture and also stimulates collagen and elastin synthesis. It also transports nutrients in the blood to skin cells and serves as a cushion to lubricate and protect skin against damage.  This multifunctional component reduces irritation, promotes healing and fights inflammation processes in the skin.

Hyaluronic Acid Crosspolymer
It is a unique cross-linked non-animal derived form of hyaluronic acid that delivers water and water-soluble actives helping in the maintenance of skin’s water content when used regularly. It forms a cross-linked network on the skin’s surface providing a long-lasting moisturizing effect due to its good stability. It increases elasticity and reduces roughness. An excellent protective film that allows for smaller-sized technologies to remain topically effective while this 3D “breathable” layer prevents the skin from the damage caused by external aggressions like UV rays, dust and pollution.

Rosa Centifolia Extract 
This is a new solution extracted and prepared from Rosa Centifolia petals. It prevents the formation of wrinkles, keeps the skin supple and also reduces skin inflammation after sunburn by inhibiting the activity of hyaluronidase, an enzyme that decomposes hyaluronic acid. The extract from Rosa Centifolia petals has antioxidant properties which protect the skin from environmental damage and ageing. It has the ability to calm the skin and tone down redness.

Furcellaria lumbricalis Red Algae Extract from the Baltic Sea is a powerful protector against free radical damage, it also prevents the formation of an enzyme that causes the deprivation of collagen. The amino acids in algae firm and renew skin tissue while fatty acids fight inflammation, unify the complexion and make the surface of the skin smooth, soft and silky.

Flower Acids® are obtained from chalices of a subtropical Hibiscus sabdariffa. We only use beige petals that are harvested in winter to ensure the best quality due to their high organic acid content. The pyruvic acid in FLOWERS ACIDS® has proved to be highly efficient without causing irritation. Flower acids improve skin structure and its brightness, decrease ageing signs, wrinkles and dark spots. They also decrease sebum production and improve hydration.

AQUAXYL™* is an “anti-dehydration shield” that reinforces the synthesis of essential lipids and proteins involved in the organisation of the corneus layer. It offers the 3D hydration hydraconcept for circulation of moisture throughout all skin layers and the boosting of hyaluronic acid. The skin barrier is reinforced in 24 hours by limiting the loss of water. In case of normal desquamation, its impact is visible in 28 days leaving the skin softer and smoother.

Niacinamide (vitamin B3) is a very stable vitamin which offers a wide range of topical benefits. It helps to get rid of pimples and acne problems and is also a popular and widely used skin-lightening ingredient. However, its activity profile goes far beyond this: niacinamide enhances the efficacy of products designed for blemished skin, dry and sensitive skin and anti-wrinkle treatment.

Depending on the percentage added, niacinamide offers different effects:
● 2-3% protects from city pollution, moisturizes and soothes, restores skin’s protective abilities
● 4% minimizes pimples and spots (in addition to aforementioned qualities)
● 5% anti-ageing properties and evens out skin tone (in addition to aforementioned qualities)

Spent Grain Wax & Shea Butter & Argan Oil* – a powerful combination of natural active ingredients that offer not only alleviation to itching but according to dermatological tests, this exact ingredient combination stopped the itching from reoccurring. Stressed skin’s redness is substantially diminished leaving the skin looking healthy and feeling soothed.
*ECOCERT approved and NATRUE certified.

Sweet Almond Oil (Prunus Amygdalus Dulcis Oil) is a light and well-absorbing oil, thus especially good for dry and sensitive skin. The oil helps to improve the skin’s blood circulation and metabolism while stimulating collagen synthesis and skin cells’ renewal. Due to its warming and muscle tension relieving properties, this oil is also widely used as a massage oil. 

Bergamot Oil (Citrus Aurantium Bergamia Fruit Oil) has cooling, vitalizing and refreshing as well as antiseptic properties. Like all other citric oils it trims skin tissues.

Sunflower Oil (Helianthus Annuus Seed Oil) consists of fatty acids which are especially useful for dry, sensitive or damaged skin. It also contains oleic acids, vitamins A, B, D, E and plenty of minerals and lecithin which are all very valuable skin nourishing components. The oil is well-absorbing and helps to maintain the skin’s natural moisture level.

Jojoba Seed Oil (Simmondsia Chinensis Seed Oil) moisturizes and softens the skin. In addition, it has antioxidative, anti-inflammatory and even healing properties (relieves acne and eczema problems, swellings and insect bites). Jojoba seed oil helps to maintain the skin’s elasticity.

Grape Seed Oil (Vitis Vinifera Seed Oil) consists of antioxidative polyphenols which help to reduce ageing signs. The oil contains anti-inflammatory as well as anti-bacterial properties and provides excellent protection against free radical damage.

Argan Oil is advocated as a moisturizing oil, effective against the flaking of the skin. This oil has also medicinal uses against rheumatism and the healing of burns. The oil is used in the treatment of mature skin. In D’DIFFERENCE series argan oil is used for its replenishing and smoothing purposes.


Thousands of hours have gone into the development and testing of D’DIFFERENCE products, so use them as recommended in order to get the maximum benefit and the most visible results.

Follow the routines we prescribe, even though applying cream probably isn’t your first priority when you’re tired in the evening. You don’t need much D’DIFFERENCE – less is often more – but taking a few minutes in the evening will result in glowing skin, as well as peace of mind.

It’s important to know that cleansing is the most important step in your skincare routine. An expensive cream is not a cure-all, and it can only do its work if the skin has been properly cleaned and prepared.


Remember to apply creams with the ring fingers of both hands, which is your hands’ softest skin. Pat, never drag, as skin on skin does harm. This is especially important when it comes to eye creams!


The Nordic region is known for its pure air and pristine nature. Around 55 percent of Estonia is forested, due in part to our reverence for all things natural. Estonians love to walk in forests, swim in clean lakes, and knowledge of edible plants is passed down through the generations.

This Nordic love of nature is an integral part of D’DIFFERENCE’s philosophy, as well. It’s why we choose the simplest, purest approach to skin care – our products offer everything the skin needs and no more. Because to live simply and purely is to live well.

It is particularly difficult to get glowing skin in Nordic conditions. The climate constantly changes, and skin changes accordingly. What skin needs most is to get back in balance, which is the very basis for healthy skin. D’DIFFERENCE products are formulated to restore that balance under the most difficult climatic conditions.

Get yours in the US!

Shop for your favorite D’DIFFERENCE skincare products now in in the United States!

Experience our innovative, high-quality skincare solutions, designed to rejuvenate and nourish your skin.

To make your shopping experience even better, we’re offering free shipping on all orders of $100 and up.

Explore our range of exceptional products and transform your skincare routine with D’DIFFERENCE today!

  • Free shipping on orders $100 and up.

  • Fast 3-day delivery with DHL Worldwide. 

  • Free sample with every order. 

  • 20% your first order from the US!

  • Pay safely using Mastercard, Visa, or PayPal.

„Although I am engaged in business, I am first and foremost a doctor. I still practice medicine because helping patients is the most gratifying thing I do. Also, I sometimes find that my most challenging cases provide impetus for new product creation. And everything I learn in medicine I put into the products D’DIFFERENCE® creates“

Produced by
AS Chemi-Pharm
Harju maakond, Saku vald
Tänassilma küla, 76406
Tänassilma tee 11
Estonia EU
VAT EE100310771
E-mail: [email protected]

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