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    Skincare tested on all skin types, in all climates, across all continents

  • Get natural- and high-performance in a single product


    Skincare tested on all skin types, in all climates, across all continents




„Although I am engaged in business, I am first and foremost a doctor. I still practice medicine because helping patients is the most gratifying thing I do. Also, I sometimes find that my most challenging cases provide impetus for new product creation. And everything I learn in medicine I put into the products D’DIFFERENCE creates“


D’DIFFERENCE is the science of skincare. Invented by an MD, developed by chemists in our own labs, and produced with cold-mixing technology, our active ingredients are 100-percent natural.

We use organic ingredients when possible, but we are not blindly devoted to them — what best creates healthy skin is maintaining the skin’s proper pH level. Our credo: minimum ingredients make for maximum impact.

D’DIFFERENCE is a natural version of products originally created for use by physicians to solve acute clinical problems. True to our medical roots, D’DIFFERENCE products are formulated through evidence-based results from extensive testing, yet our Nordic heritage means we embrace the natural, living as part of nature, never separate.

In this age of eco, it seems everyone with a kitchen is creating skincare products. But we take pride in the fact that ours are backed by science, meet ISO 9001 production standards, and leave the skin healthy both inside and out.


Thousands of hours have gone into the development and testing of D’DIFFERENCE products, so use them as recommended in order to get the maximum benefit and the most visible results.

Follow the routines we prescribe, even though applying cream probably isn’t your first priority when you’re tired in the evening. You don’t need much D’DIFFERENCE – less is often more – but taking a few minutes in the evening will result in glowing skin, as well as peace of mind.

It’s important to know that cleansing is the most important step in your skincare routine. An expensive cream is not a cure-all, and it can only do its work if the skin has been properly cleaned and prepared.


Remember to apply creams with the ring fingers of both hands, which is your hands’ softest skin. Pat, never drag, as skin on skin does harm. This is especially important when it comes to eye creams!



The goal of skin care is to ensure our skin’s best functioning. Depending on skin type or skin condition and its peculiarities, it is important to consider different climate and weather conditions as well as the choice of the most suitable skincare product.
What do you need to know about different skin types?

A person is said to have NORMAL SKIN when skin’s natural lipid and moisture levels are balanced. The skin looks soft and smooth and the skin pores are almost invisible. Sadly, this balance almost never occurs in real life. 
How to treat it?
Normal skin needs hydration and moisture! Daily care is so important in order to maintain this beautiful tone and complexion – a mild cleanser (I suggest a milk that can be washed off), a hydrating toner, a balancing moisturizer and eye creamExfoliate your skin once per week and follow up with a moisturizing mask once or twice per week.

DRY SKIN lacks sebum. It can be identified by a rough and flaky skin surface that is very responsive to different weather conditions. It is also thin, and the compexion is pale and grayish. In case of dry skin, premature ageing signs become visible, especially around the eyes and lips. An interesting fact is that dry skin does not absorb products easily. At times, the skin can become so dry that eczema is triggered. Skin is more likely to react to products and it can make you feel as if no skincare product is suitable for you. Sounds bad…? But there are good news – skincare comes to the rescue and it really works!
How to treat it? Look for moisturizers that have a word nourish in their product descriptions. Other than that cleanse with a milk, follow up with a hydrating toner, use enzymatic or acid peel (no beads for you!) at least 2 times per week, use a serum twice daily, keep your day care and night care separate. Your skin needs pampering to the max, soothing and hydrating masks are highly recommended!
There is no sleeping mask in our product line but we can recommend a balm for your dry skin to recover during the night and regenerate healthy tissue.

DEHYDRATED SKIN lacks water. It looks dull, feels tight and can often be sensitive. Sometimes it may produce too much oil to compensate and this may result in breakouts. The pores can be either large or small. Dehydrated skin absorbs products very quickly. It affects your make up too as the skin absorbs water from the foundation and can thus make the skin look patchy.
How to treat it? The best way to moisturize the skin deeply is to use a serum. If the skin is otherwise shiny but you feel it being dry at the same time, you shouldn’t use a heavy moisturizer. Instead, use a rehydrating serum first and then apply a light moisturizer. That method works! We suggest exfoliating once or twice per week followed by a moisturizing mask. Choosing a cleanser can be tricky – we suggest using a milk that can be washed off if you love the clean feeling that comes with washing. Then use a toner, twice a day, as goes for all the other skin types too.

SENSITIVE SKIN is actually not a skin type. It is a skin condition that may occur at any time of your life. Therefore, you should also consider your skin type when selecting products. Emotions, wrong products and outside factors may easily affect it. You might recognize it from the following reactions – skin redness, roughness, visible capillaries, etc. Skin’s natural fat excretion and moisture levels are usually low. Histamine release, a skin process that appears as skin redness, needs to be taken under control. Eczema and rosacea are also characteristic of sensitive skin but they require special treatment. Rosacea is a disease affecting the small capillaries. Eczema is an inflammation in the outer layers of the skin, especially in the epidermis. All types of eczema are characterized by itching which is its best indicator. Choosing the right skincare product is very important. Add niacinamide to your routine and make sure  that all products are gentle and soothing.

OILY SKIN is identified when there is a little oily luster on the skin that is caused by intensive fat excretion. The skin itself may look pale and have a yellow tone, and the pores are visible. There are a variety of reasons why you have oily skin but some of the most common are hormonal, genetic or a result of using wrong skincare products. Oily skin may also be the cause of pimples and acne.
How to treat it? Rule number one is – do not dry out your skin! If you allow the surface of your skin to become dry, then signals are sent out to your body and the body will begin to produce even more sebum. This is a very common mistake made, and unfortunately, not so easily resolvable. Hydrating with light and quickly absorbing products is important. We would recommend bathing in hyaluronic acid if this could be possible ;-) Effective but gentle cleansers, acid toners, mild exfoliators, balancing and calming serums together with light emulsions make the difference. With the “happy” combination of oily and mature skin, we recommend hydrating creams from our Cell Innovation line. When your skin becomes oily during the day, you can use blotting papers.

ACNE is a skin condition that can be caused by:
– Hormones – related to women`s monthly cycle and menopause. It can cause „adult acne“, the overproduction of oil and slower shedding pimples can appear due to dead skin cells, and they can be aggressive.
– Bacteria – Propionibacterium Acne is the bacteria that gives this skin condition a name. All it needs is the perfect environment to spread. When you see red cysts, do not try to pick them! It does not help and they leave a scar. They have to be treated with special products.
– Inflammation – caused by stress or food or some illness.
– Sensitivities – allergies, reactions to products, reactions to foods/environments.

How to treat it? Every skin is different but with acne you need to pay extra attention to the hydration of your skin. Exfoliation is also important. Go to your dermatologist for advice and in case of prescribed antibiotics, use probiotics for counteraction. 
Do not put toothpaste or vodka on pimples (shivers…), exfoliate! AHA acids (lactic, glycolic, malic, etc) and BHA acid (salicylic acid) are all good. Last but not least – pay attention to your food! There is a lot of information available online related to this subject, investigate, and if you find it necessary, consult with nutrition specialists to plan out your diet plan.

The majority of people have COMBINED SKIN. It means that skin looks oily on the face’s T-zone (forehead, nose) areas but dry around the cheeks. The first wrinkles usually form in dry areas. Tricky? Yes, but again, hydration and light products work well.
How to treat it? Make sure that you cleanse well, tone with a hydrating mist, exfoliate 1-2 times per week, use a hydrating serum and a light moisturizer.

„DEMANDING” or MATURE SKIN can be determined by dry areas, poor elasticity, premature ageing signs, unbalanced moisture and fat levels, skin irritation due to stress and severe weather conditions, and inefficient skin care. People usually talk about lines and wrinkles that are formed when collagen fibers age and harden. The hardening occurs mainly due to UV-radiation, environmental pollution and free radicals. Free radicals are dangerous oxygen molecules that attack cells. In order to look and feel good, go for good cleansers, effective serums, immediate effect masks and replenishing skincare. We suggest to choose separate day and night creams. Peels are good too, either acidic or enzymatic, used 2-3 times per week.

In D`DIFFERENCE and D`DIFFERENCE FOR MEN lines, you can find solutions for all skin types. No worries ;-)

One extra piece of advice for all skin types and conditions – avoid mineral oil (paraffinum liquidum), silicones, PEGs, and colourants in skincare products. The natural alternatives are available and perform much better.

As we are not pshycics (and that is unfortunate) then please contact us for personal consultation and samples at: [email protected]

Please remember – acclimating to new products and series takes about 2-8 weeks. You want to see immediate results and it seems to take ages, we understand. At first, your skin may even become worse – it may become dry and some pimples may form. This is part of the adjusting process, and it is normal. Still, you should never tolerate a lasting sense of discomfort. If the discomfort lasts, you should stop the treatment and contact a skin therapist.

Week 1: Wait 2-3 days after the first application. Thereafter, apply once every other day.
Week 2: Apply every other day morning and/or night depending on the specifics of the product.
Week 3: Apply every day morning and/or night depending on the specifics of the product.

We usually recommend that you start with a cleanser and a cream, and wait a week before adding a serum. The week guide applies especially to all high quality and slightly more active and more concentrated skincare products. It especially applies to products that contain acids, vitamins A and C, as well as peptides and stem cells.


D’DIFFERENCE and D’DIFFERENCE FOR MEN products contain a great variety of active ingredients, each of them having its own unique and valuable features. We only use cold-mixing methodology for processing raw materials and mixing the components to ensure the production with the best quality.

HYDRESIA® emulsion* consists of natural oleosomes from safflower seeds, and its function is to retain the healthy level of moisture and nutrients in the skin. Safflower oleosomes act as natural water and nutrients’ reservoirs. When skin needs additional moisturizing or nutrition, oleosomes help to release them gradually, making the skin look youthful and bright during longer periods of time. As HYDRESIA® emulsion is a main ingredient in a majority of our products, this time-release system is a common feature of D’DIFFERENCE products. We purchase the emulsion from Canada, it is tested on all continents, on different ages and skin types. Its performance and skin tolerance is excellent, and we absolutely adore it!
*ECOCERT approved

– This ingredient can be found in our face and body creams

Plant-Derived Stem Cells Extract that is included in D’DIFFERENCE Cell Innovation products and D’DIFFERENCE FOR MEN Age Difference Face Cream. It is a very efficient anti-ageing component stimulating collagen synthesis and the renewal of skin cells, it decreases the depth and length of wrinkles and also prevents the formation of new wrinkles. Plant-derived stem cells extract, processed in a way that all valuable properties of stem cells have been retained, is the most unique and innovative approach used in natural anti-ageing skin care products.

Collagen is a natural protein that provides our bodies with structural support — the fibrous, elastic, connective tissue in our bodies that holds us together. Collagen is a part of the natural make-up of our tendons, ligaments, joints, muscles, hair, skin, etc. As we age, the production of collagen in our body slows down. On the outside we see our skin start to wrinkle and lose its youthful radiance due to the breakdown of connective tissue. Since the plant stem-cell component has the potency to promote collagen production and to activate cells, you can expect your skin to rejuvenate. The component is an excellent functional ingredient for cosmetics enabling substantial cell activation and collagen synthesis to improve fine lines and wrinkles.

– This ingredient can be found in our Cell Innovation line

Persian Silk Tree Extract*
For the first time in the cosmetics industry, an active ingredient is demonstrating a lifting action on sagging upper eyelids. It offers a gentle alternative to invasive surgery to lift the upper eyelid, reduce crow’s feet wrinkles, fade away dark circles and diminish puffiness.
*ECOCERT approved

 – This ingredient can be found in our eye creams 

Peptides, Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 are there to ”attack” the dark circles. These powerful peptides reinforce firmness and tone of the eye area. They also activate the elimination of blood originated pigments responsible for the colour in the dark circles and local inflammation. Peptides are one of the most efficient ingredients to absorb the pigment in the blood that causes the colour to appear. The results are visible to the naked eye! When used regularly, it can help to reduce the discoloration at an amazing speed.

– This ingredient can be found in our 5D Lifting Eye Cream and 4D Rescue Eye Cream for Men  

Whitening Compound* is a multifunctional skin lightener for all skin types which significantly reduces the colour and size of age spots, and decreases and cleaves pigmentation. All D’DIFFERENCE White Beauty products include the 7 most effective natural whitening extracts which are selected from 100 different plants.
*ECOCERT approved

This ingredient can be found in our White Beauty line

Hyaluronic Acid* is found in every human body. It is the key component of the extracellular matrix which is the space filler of the supporting scaffold cells. It allows skin cells to retain moisture and also stimulates collagen and elastin synthesis. It also transports nutrients in the blood to skin cells and serves as a cushion to lubricate and protect skin against damage. Hyaluronic acid fights ageing by stimulating the growth of new cells and the production of collagen and elastin. This function helps to reduce existing wrinkles and to prevent future ones from appearing. This multifunctional component reduces irritation, promotes healing and fights inflammation processes in the skin. Last but not least, it serves as the free radical scavenger and an antioxidant helping to protect the skin from ageing effects caused by excessive sunlight exposure.
We use this “miracle component” in different molecular weights in order to influence all the layers of the skin.
*ECOCERT approved

– This ingredient can be found in our Cell Innovation line and also in all serums and masks

Hyaluronic Acid Crosspolymer
It is a unique cross-linked non-animal derived form of hyaluronic acid that delivers water and water-soluble actives helping in the maintenance of skin’s water content when used regularly. It forms a cross-linked network on the skin’s surface providing a long-lasting moisturizing effect due to its good stability. It increases elasticity and reduces roughness. An excellent protective film that allows for smaller-sized technologies to remain topically effective while this 3D “breathable” layer prevents the skin from the damage caused by external aggressions like UV rays, dust and pollution.

– This ingredient can be found in our 5D Rejuvenating Serum

Rosa Centifolia Extract 
This is a new solution extracted and prepared from Rosa Centifolia petals. It prevents the formation of wrinkles, keeps the skin supple and also reduces skin inflammation after sunburn by inhibiting the activity of hyaluronidase, an enzyme that decomposes hyaluronic acid. The extract from Rosa Centifolia petals has antioxidant properties which protect the skin from environmental damage and ageing. It has the ability to calm the skin and tone down redness.

– This ingredient can be found in our Cleansers and 5D Revitalizing Serum

Furcellaria lumbricalis Red Algae Extract from the Baltic Sea is a powerful protector against free radical damage, it also prevents the formation of an enzyme that causes the deprivation of collagen. The amino acids in algae firm and renew skin tissue while fatty acids fight inflammation, unify the complexion and make the surface of the skin smooth, soft and silky.

– This ingredient can be found in our 5D Smoothing Serum5D Faceglow Peel5D Bodyglow Peel

Flower Acids® are obtained from chalices of a subtropical Hibiscus sabdariffa. We only use beige petals that are harvested in winter to ensure the best quality due to their high organic acid content. The pyruvic acid in FLOWERS ACIDS® has proved to be highly efficient without causing irritation. Flower acids improve skin structure and its brightness, decrease ageing signs, wrinkles and dark spots. They also decrease sebum production and improve hydration.

– This ingredient can be found in our 5D Smoothing Serum5D Faceglow Peel5D Bodyglow Peel and 4D Delicate Exfoliator

AQUAXYL™* is an “anti-dehydration shield” that reinforces the synthesis of essential lipids and proteins involved in the organisation of the corneus layer. It offers the 3D hydration hydraconcept for circulation of moisture throughout all skin layers and the boosting of hyaluronic acid. The skin barrier is reinforced in 24 hours by limiting the loss of water. In case of normal desquamation, its impact is visible in 28 days leaving the skin softer and smoother.
* This ingredient is ECOCERT approved

– This ingredient can be found in our Cleansers and Face Care products

Niacinamide (vitamin B3) is a very stable vitamin which offers a wide range of topical benefits. It helps to get rid of pimples and acne problems and is also a popular and widely used skin-lightening ingredient. However, its activity profile goes far beyond this: niacinamide enhances the efficacy of products designed for blemished skin, dry and sensitive skin and anti-wrinkle treatment. Latest data on the protection potential of niacinamide for UV challenged skin makes it the ideal companion for your daily skin care routine. And it also protects us from the harmful effects of blue light (computers, phones etc).

Depending on the percentage added, niacinamide offers different effects:
● 2-3% protects from city pollution, moisturizes and soothes, restores skin’s protective abilities
● 4% minimizes pimples and spots (in addition to aforementioned qualities)
● 5% anti-ageing properties and evens out skin tone (in addition to aforementioned qualities)

– This ingredient can be found in the majority of our products – 4D Moisturizing Day Cream5D Whitening Face Cream5D Revitalizing Face SerumAnti-Redness Night Cream – just to mention a few

Spent Grain Wax & Shea Butter & Argan Oil* – a powerful combination of natural active ingredients that offer not only alleviation to itching but according to dermatological tests, this exact ingredient combination stopped the itching from reocurring. Stressed skin’s redness is substantially diminished leaving the skin looking healthy and feeling soothed.
*ECOCERT approved and NATRUE certified.

 This ingredient can be found in Golden Jojoba Balm4D Nourishing Night Cream4D Soothing Hand Cream and 4D Moisturizing Body Lotion

Sweet Almond Oil (Prunus Amygdalus Dulcis Oil) is a light and well-absorbing oil, thus especially good for dry and sensitive skin. The oil helps to improve the skin’s blood circulation and metabolism while stimulating collagen synthesis and skin cells’ renewal. Due to its warming and muscle tension relieving properties, this oil is also widely used as a massage oil. Most of D’DIFFERENCE and D’DIFFERENCE FOR MEN creams and lotions contain sweet almond oil.

Bergamot Oil (Citrus Aurantium Bergamia Fruit Oil) has cooling, vitalizing and refreshing as well as antiseptical properties. Like all other citric oils it trims skin tissues.

Sunflower Oil (Helianthus Annuus Seed Oil) consists of fatty acids which are especially useful for dry, sensitive or damaged skin. It also contains oleic acids, vitamins A, B, D, E and plenty of minerals and lecithin which are all very valuable skin nourishing components. The oil is well-absorbing and helps to maintain the skin’s natural moisture level.

Jojoba Seed Oil (Simmondsia Chinensis Seed Oil) moisturizes and softens the skin. In addition, it has antioxidative, anti-inflammatory and even healing properties (relieves acne and eczema problems, swellings and insect bites). Jojoba seed oil helps to maintain the skin’s elasticity.

Grape Seed Oil (Vitis Vinifera Seed Oil) consists of antioxidative polyphenols which help to reduce ageing signs. The oil contains anti-inflammatory as well as anti-bacterial properties and provides excellent protection against free radical damage.

Argan Oil is advocated as a moisturizing oil, effective against the flaking of the skin. This oil has also medicinal uses against rheumatism and the healing of burns. The oil is used in the treatment of mature skin. In D’DIFFERENCE series argan oil is used for its replenishing and smoothing purposes.

Dead Sea Minerals have plenty of valuable features – they regulate skin’s metabolism and balance the skin’s structure. Dead Sea Minerals consist of sulfur which is natural antioxidant and stimulates collagen synthesis and cells’ metabolism; the potassium and sodium which regulate skin`s moisture balance and help to secrete toxins; chlorine, iodine and magnesium which help to intensify cell metabolism; calcium which is required for retaining the strength of cells’ structure and for cleansing pores; bromine which is actually a natural antibiotic, etc. In addition, Dead Sea Minerals in cosmetics act as natural preservatives.


The Nordic region is known for its pure air and pristine nature. Around 55 percent of Estonia is forested, due in part to our reverence for all things natural. Estonians love to walk in forests, swim in clean lakes, and knowledge of edible plants is passed down through the generations.

This Nordic love of nature is an integral part of D’DIFFERENCE’s philosophy, as well. It’s why we choose the simplest, purest approach to skin care – our products offer everything the skin needs and no more. Because to live simply and purely is to live well.

It is particularly difficult to get glowing skin in Nordic conditions. The climate constantly changes, and skin changes accordingly. What skin needs most is to get back in balance, which is the very basis for healthy skin. D’DIFFERENCE products are formulated to restore that balance under the most difficult climatic conditions.


Reward yourself with 20% off
one order when joining our
Skin Guardians email list.*

* Limited to one promotional code per order. Valid on orders over 50€

Reward yourself with 20% off
one order when joining our
Skin Guardians email list.*

* Limited to one promotional code per order. Valid on orders over $50.

Produced by
AS Chemi-Pharm
Harju maakond, Saku vald
Tänassilma küla, 76406
Tänassilma tee 11
Estonia EU
VAT EE100310771
E-mail: [email protected]

D'DIFFERENCE® is a registered trademark of AS CHEMI-PHARM. All rights reserved.

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