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SKIN is our body’s largest organ, covering entire body. Skin protects us against environmental influences (e.g. heat, light, injury, infection etc.), regulates body temperature, stores water and fat, prevents water loss and entry of bacteria as well as acts as a sensory organ.

Do you know that…

  • Every adult person has about 2 m² of skin;
  • The average weight of the skin is about 14 kg, forming about 20% of total body mass;
  • The skin holds about 25% of whole water storage of our bodies;
  • One square centimeter consists of:
    • 600 000 skin cells
    • 5000 sensory cells
    • 4 meters of nerves
    • 100 sweat glands
    • 1 meter of blood vessels
    • 15 sebacious glands
    • 5 hairs
    • 150 000 melanocytes

Skin’s normal pH level is 5-6. In order to ensure skin’s maximum protection ability, pH should be held in this range. Talking about oh-so-popular acids (yes, we love them too!) the difference in the pH-value is what decides the strength of the product. The lower the pH, the stronger the exfoliation. All acids exfoliate, even when they are in leave-on products.

Condition of the skin depends on different factors. Choosing a right skincare product is one of the key factors for keeping your skin in good shape. High-quality cosmetics can prevent skin ageing, protect the skin against environmental damages (including UV-radiation) and alleviate skin problems – flaking, acne, eczemas, etc.

The skin is made up of 3 layers – epidermis, dermis and hypodermis – each of them performing its specific function.

The outer layer of the skin is called EPIDERMIS, which functions as a barrier between our body and environment.  It’s thickness varies from 0,05 mm on the eyelids to 1,5 mm on the palms and soles of the feet and it is formed by a thin layer of lipids. When skin cells age and perish, the body will immediately remove the upper layer of the skin replacing it with new skin cells. Epidermis’ renewal time is approximately 3-4 weeks. Epidermis contains melanocytes which determine skin tone and protection ability against UV-radiation. Antigen-processing Langerhans cells of bone marrow origin, and pressure-sensing Merkel cells of neural crest origin are also essential parts of the epidermis.

The middle layer of the skin – DERMIS – consists of blood vessels, hair follicles, sweat glands, collagen and elastin fibers, fibroblasts and nerves. Dermis regulates body temperature, supplies the epidermis with nutrient-saturated blood and provides the skin with elasticity and strength. It is thicker than the epidermis, 1.5 to 4 mm thick.

Subcutaneous layer of the skin – HYPODERMIS – is the deepest layer of the skin, which consists of a network of collagen and fat cells. This part of the skin protects our organs against injury („shock absorption”) and conserves our health.


The goal of skincare is to ensure our skin’s best functioning. Depending on skin type or skin condition and its pecularities, different climate and weather conditions, a choice of right and suitable skincare product, is essential to condsider.
Whatdo you need to know about different skin types?

A person is said to have a NORMAL SKIN when skin’s natural lipid and moisture levels are balanced. The skin looks soft and smooth and skin pores are almost invisible. FYI – this balance almost never happens in real life and it is so sad. How to treat it? Normal skin needs hydration and moisture! Daily care is so important, in order to maintain this beautiful tone and complexion – a mild cleanser (I suggest a milk that can be washed off), a hydrating toner, a balancing moisturizer, and eye creamExfoliate your skin once per week and follow up with a moisturizing mask once or twice per week.

DRY SKIN lacks sebum. It is identified when the skin surface is rough, flaky and easily responsive to weather conditions. Thin too. With pale and grayish complexion. In case of dry skin premature ageing signs become visible, especially around the eyes and lips. An interesting fact is, that dry skin does not absorb products easily. At times, the skin can become so dry that eczema develops. Skin is more likely to react to products and it can make you feel as if no skincare product is suitable for you. Sounds bad…good news, skincare comes handy and it works!How to treat it? Look for moisturizers that have a word nourish in their product descriptions. Other than that cleanse with a milk, follow up with a hydrating toner, use enzymatic or acid peel(no beads for you!) at least 2 times per week, use a serum twice daily, keep your day care and night care separate. Your skin needs pampering to the max, soothing and hydrating masks are highly recommended! There is no sleeping mask in our product line, but if your dry skin needs to recover and regenerate healthy tissue, we can recommend a balm.

DEHYDRATED SKIN lacks water. It looks dull, feels tight and can often be sensitive. Sometimes it may over-produce oil to compensate and this results in breakouts. The pores can be both – large and small. Dehydrated skin absorbs products very quickly. It affects your make up as well, since the skin absorbs water from the foundation and skin can look patchy. How to treat it? The best way to provide moisture deep in the skin is to use a serum. If you are shiny, while at the same time feel dry, you shouldn’t use a heavy moisturizer.  Instead you should use a light moisturizer plus a rehydrating serum underneath. That is the trick! We suggest exfoliating once or twice per week followed by a moisturizing mask. Choosing a cleanser can be tricky – we suggest using a milk that can be washed off if you love the clean feel that comes with washing. Then a toner, twice daily as for all other skin types.

SENSITIVE SKIN is not a skin type. It is a skin condition that may occur at any time of your life. Therefore, you should also consider your skin type when selecting products. Emotions, wrong products and outside factors may easily influence it. The following reactions may occur – skin redness, roughness, visible capillaries, etc. Skin’s natural fat excretion and moisture level are usually low. Histamine release, a process that happens in the skin and shows as reddness on the skin, needs to be taken under control. Eczema and rosacea are also types of sensitive skin but they require special treatment. Rosacea is a disease of small capillaries. Eczema is an inflammation in the outer layers of the skin, especially the epidermis. All types of eczema are characterized by itching, which is the best indicator of eczema. Choosing a right skin care product is very important. Look for niacinamide in your routine. All products should be gentle and soothing.

OILY SKIN is identified when there is a little oily luster on the skin caused by intensive fat excretion. The skin itself may look pale with yellow tone and pores are visible. There are many causes for getting oily skin, but some of the most common ones are: hormonal, genetic or a result of using wrong skincare products. Oily skin may cause pimples and acne. Sadly. How to treat it? Rule number one is – do not dry out your skin! If you allow the surface of your skin to become dry, then signals are sent out to your body, and in turn, the body will begin to produce even more sebum. This is a very common mistake, unfortunately not so easy to fix. Hydrating with light and quickly absorbing products is important. We would recommend bathing in hyaluronic acid if this could be possible;-) Effective but gentle cleansers, acid toners, mild exfoliators,  balancing and calming serums together with light emulsions make the difference. With the “happy” combination of oily and mature skin, we recommend hydrating creams from our Cell Innovation line. When your skin becomes oily during the day, you can use blotting papers.

ACNE is a skin condition that can be caused by:
– Hormones – related to women`s monthly cycle and menopause. It can cause what we call adult acne – over production of oil and due to dead skin cells slower shedding pimples can appear and they can be agressive.
– Bacteria – Propionibacterium Acnes is the bacteria that gives this skin condition a name – all it needs is the perfect environment to spread. When you see red cysts, do not try to pick them! It does not help and they leave a scar. They have to be treated with special products.
-Inflammation –caused by stress or food or some illness.
-Sensitivities – allergies, reactions to products, reactions to foods/environment
Every skin is different, but with acne you need to pay extra attention to the hydration of your skin and exfoliation is important too. Go to your dermatologist for advice and in case of prescribed antibiotics, use probiotics for counteraction. Do not put toothpaste or vodka on pimples (shivers…), exfoliate! AHA acids (lactic, glycolic, malic etc) and BHA acid (salicylic acid) are all good. Last but not least – your food! There is a lot of info related to the subject, read and if you find it necessary consult with specialists to find your regime.

The majority of people have COMBINED SKINIt means that skin looks oily on face’s T-zone (forehead, nose) areas, but dry around the cheeks. The first wrinkles usually form on dry areas. Tricky? Yes, but again hydration and lightness of the product work well. How to treat it? Make sure that you cleanse well, tone with a hydrating mist, exfoliate 1-2 times per week, use a hydrating serum and a light moisturizer.

„DEMANDING” or MATURE SKIN can be determined as following – dry areas, poor elasticity, premature ageing signs, unbalanced moisture and fat levels, skin irritation due to stress, inappropriate weather conditions and inefficient skincare. People usually talk about lines and wrinkles. They are formed when collagen fibers age and harden. The hardening occurs mainly due to UV-radiation, environmental pollution and free radicals. Free radicals are dangerous oxygen molecules that attack cells.  In order to look and feel good, go for good cleansers, effective serums, immediate effect masks and replenishing skincareDay and night creams are suggested to be chosen separately! Peels are good too, acidic or enzymatic 2-3 times per week!

In D`DIFFERENCE and D`DIFFERENCE FOR MEN lines, you will find solutions for all skin types. No worries;-)
One piece of advice for all skin types and conditions-Avoid mineral oil (paraffinum liquidum), silicones, PEGs, colourants in care products. The natural alternatives are available and much better.

As we are not pshycics (and that is unfortunate) then please contact us for personal consultation and samples at:

Please remember – Acclimating to new lines and new products takes about 2-8 weeks. You are waiting for results and it seems ages but there is nothing we can do about it. At first, your skin may become worse – it may become dry and some pimples may form. This is a part of the adjusting process and it is normal. Still, you should never tolerate a lasting sense of discomfort. If discomfort lasts, you should stop the treatment and contact a skin therapist. What can you do to avoid this?
Week 1: Wait 2-3 days after the first application. Thereafter, apply once every other day.
Week 2: Apply every other day morning and/or night depending on the specifics of the product.
Week 3: Apply every day morning and/or night depending on the specifics of the product.

We usually recommend that you start with cleanser and cream and wait a week before adding a serum. The week guide applies specially to all high quality and slightly more active and more concentrated skincare products. It especially applies to products that contain acids, vitamins A, C, peptides, stem cells.

Produced by
AS Chemi-Pharm
Harju maakond
Saku vald
Tänassilma küla, 76406
Tänassilma tee 11
Estonia EU

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